硫黄이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

Effect of Sulfur on Blood Alcohol Level in Rabbits

Sulfur is a simple element, and has been known as an important component of various enzymes and other organic substances. It was once used in the pyrotherapy of dementia praecox and general paresis and a small dose of it was used in neurosis. The author conducted an animal experiment to investigate the effect of sulfur on blood alcohol level, because many investigators have suggested that many psychotropic drugs elevated blood alcohol level in rabbits. The experiment was done on mature rabbits of both sexes. The control group was given alcohol alone, and the experimental groups were given various oral doses of sulfur, that is, 100mg/kg for 5 days, 100mg/kg for lOdays, 200 m g / k g for 5 days and 200mg/kg for lOdays, respectively, before alcohol administration. The last dose was given one and a h alf hour before alcohol adm inistration. In all groups, 5. Oml/kg of 20% ethanol solution was given intravenously. And at 15 and 45 minutes after alcohol injection blood specimens were obtained by cardiac puncture. The blood alcohol levels were determined by Cavett’s method. As the results, comparing with the control group, sulfur, when administered in a dose of lOOmg/kg of body weight daily for 5 days, did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. But, sulfur, when administered in a dose of lOOmg/kg of body weight daily for lOdays and 200mg/kg of body weight daily for 5 days, elevated the blood alcohol level significantly at 15 minutes after alcohol administration but not at 45minutes, and, when administered in a dose of 200mg/kg of body weight daily for lOdays elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. It is concluded that sulfur elevates the blood alcohol level in rabbits when the dose is sufficient, and the duration is long enough