Doxepin is a tricyclic antidepressant and is a derivative of dibenzoxepine, which is known to be effective in depressed patients, showing anxiety and sleep disturbance. The author conducted an animal experiment to investigate the effects of this antidepressant on blood alcohol level, because many investigators have suggested that any new psychotropic drug should be tested for their interaction with alcohol. The expermient was done on mature rabbits of both sexes. The control group was given alcohol alone, and the experimental groups were given not only alcohol but also various oral doses of doxepin, namely, 10mg/kg for 5 days, 10 mg/kg for 10 days, 25mg/kg for 5 days, and 25mg/kg for 10 days, respectively. The last dose was given one and a half hour before alcohol administration. In all groups, 5. Oml/kg of 2096 ethanol solution was given intravenously and at 15 and 45 minutes after alcohol injection, blood specimens were obtained by cardiac puncture. The blood alcohol levels were determined by Cavett’s method. Doxepin, when administered orally in a dose of lOmg/kg of body weight daily for 5 or 10 days, did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration, but when administered orally in a dose of 25mg/kg of body weight daily for 5 or 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. It is concluded that doxepin elevates the blood alcohol level in rabbits at a high dose.
서 론
실험재료 및 실험방법
실험 결과
고 찰
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