단순 및 연성전기충격요법에 의한 혈청 Cortisol5 Prolactin 및 성장 Hormone 값들의 변화

Changes of Serum Cortisol, Prolactin and Growth Hormone values by Plain and Softening Electroconvulsive Therapy

Recently it has been shown in numerous experimental studies that a series of electroconvulsive therapy (ECT) affects neurohormonal function in man, though the results of the studies have not yet confirmed the mechanisms of ECT. The authors measured serum cortisol, prolactin and growth hormone (GH) values before and after the induction of plain and softening ECT to trace if there is any significant quantitative change. The subjects consisted of 26 cases of plain ECT group and 9 cases o f softening ECT group. ECT was induced by the application of 110 volts for a period 0.3ᅳ2.0 sec., using bitemporal electrodes. Serum cortisol, prolactin and GH were measured by radioimmunoassay technique. The results were as follows； 1. It was revealed that cortisol value in the female group and the GH value in the male group increased significantly follow ing ECT, while prolactin value of both sex groups increased almost equally. 2. In plain ECT group, cortisol value and GH value increased significantly at 15,30,60 minutes follow ing the treatment. In the softening ECT group, significant increases were noted in the cortisol value at 15,30, 60 minutes follow ing the treatment and GH value at 15, 30,60 and 120 minutes following the treatment, while prolactin value increased without statistical significance. 3. It was considered that while the changes in the values of cortisol and of prolactin following ECT might be regarded as non-specific, the increase in the value of GH after ECT might have some specific meanings which may well require further verification.