Nomifensine is a new antidepressant, differing from others in its pharmacological profile, a derivative of isoquinoline, which is known to inhibit dopamine uptake as well as norepinephrine uptake. The author conducted an animal experiment to investigate the effects of this new antidepressant on blood alcohol level, because many investigators have suggested that any new psychotropic drug should be tested for their interaction with alcohol. The experiment was done on mature rabbits of both sexes. The control group was given alcohol alone, and the experimental groups were given not only alcohol but also various oral doses of nomifensine, namely, 25mg/kg for 5days, 25mg/kg for 10 days, 50mg/kg for 5days, and 50mg/kg for 10 days, respectively. The last dose was given one and a half hour before alcohol administration. In all groups, 5. Oml/kg of 20% ethanol solution was given intravenously and at 15 and 45 minutes after alcohol injection blood specimens were obtained by cardiac puncture. The blood alcohol levels were determined by Cavett’s method. There was no significant difference between control and all experimental groups in blood alcohol level at both 15 and 45 minutes after alcohol administration. It is concluded that nomifensine does not elevate the blood alcohol level in rabbits
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실험재료 및 실험방법
실험결과
고 찰
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