精神分裂症患者에서 抗精神病藥物과 瘦攀發作

Antipsychotics and Convulsive Seizure in Schizophrenics.

The auther studied on antipsychotic-induced seizure in non-epileptic hospitalized schizophre-- nics and it’s occurrence. After excluding known epileptics, the auther S3l33tei 78 patients (45 male3, 33 females) who had bssn hospitalized in the National Mental Hospital during the psriod from Jan, 1 1978 to Jun 3 3D 1930, and confirm ed to have seizure attack while taking an-ipsychotics by the nurses or doctors. The relationship between the seizure attack and antipsychotics was studied in 19 patients who had no preveous history of saizure before administration of antipsychotics and were diagn- 033d as schizophrenia by DSM III among ths primarily selected 78 patients. The results were as follows; 1) There were 11 males and 8 females. The age ranged from 19 to 33 years old. The occurrence of ths antipsychotic-induced seizure in scizophrenics was 0.85%. 2 ) Ghlorpramzins recsiving patients accounted for 73.996 of the subjects. The occurrence of convlsion was slightly higer in the patients with polypharmacy (5 .796) than those with monopharmacy (42.1% ). 3) The duration of antipsychotic therapy before occurence of seizure averaged 14.9 months, and 57.9% of the patients had convulsive seizure within 1 year. 4) Seizure occurred in 63. 1% of the patients within 10 days after the sudden increases or decreases over previous dosage, or the sudden change of antipsychotics. 5) The incidence of convulsion was twice as higher in the patients undergone EST in the past than the control group； the diffenence was statistically significant by p < 0.0 5. 6) The electroencephalogram taken within 10 days after occurrence of seizure showed abnormalities in 57.9% of the patients.