血發 Chlorpromazine濃度와 그 臨床的 意義

Plasma Chlorpromazine Level and Clinical Significance

Plasma chlorpromazine level and some aspects of the clinical significance were studied with 20 schizophrenics. The results were as follows; The (so-called) steady state of plasma chlorpromazine level was arrived at about 12th day of the drug administration in a dose of 300mg/day on a fixed maintenane regimen. Thereafter the level tended to decline slightly. After arriving at the steady state, a significant positive correlation was observed between the plasma level and the dose of the drug, both in intra-and interpatient comparisons ( r = +0.5855, p<0.025). On a fixed chlorpromazine dosage, the plasma levels showed marked interpatient differences both before and after the initial day of the steady state, though the defferences were more marked before the period of steady state. 579-584 No significant positive correlation could be identified between the plasma level and the drug side reaction, though 78% of the observed side reactions were positively related with the plasma level of 1.5 mcg/ml or above. And again, significant positive correlation was not observed between the plasma level and the clinical improvement. So-called ‘therapeutic window was considerably wide ranging between 0.5 to 2.45 mcg/ml of the plasma level.