Mesoridazine, the side chain sulfoxide derivative of thioridazine, is a well-established and effectiv e phenothiazine. Chemically, it is 10〔2(1-methyl-2-piperidyl) ethyl]-2-(m ethyl-sulfinyl) phenothiazine. Mesoridazine possesses many of the pharmacologic properties of thioridazine and chlorpromazine, and in the clinical investigation, it has attested to its efficacy and safety in paychiatric states such as schizophrenic patients, alcoholism, personality disorder, behavioral disorders in children and geriatric patients. Also, investigators suggested that any new psychotropic drugs should be tested for its interaction with alcohol, because they might precipitate the risk situation in case of consuming them concurrently. It has been lately reported that chlorprom azine, lithium ion and several other psychotropic drugs elevated the blood alcohol level in experim ental animals. In view of these reports, the author conducted an animal experiment to investigate the effects of mesoridazine on blood alcohol level in rabbits. Meterial and Method 1. The experim ental work was done on matnre rabbits of both sexes, weighing about 2kg. 2. The experim ental animals were divided into two groups ：the control and the experimental group. 3. The control group was given alcohol alone. 4. The experimental group was divided into 4 subgroups： a) alcohol plus mesoridazine, lOmg/kg of body weight daily for 5 days. b) alcohol plus mesoridazine, lOmg/kg of body weight daily for 10 days. c) alcohol plus m esoridazine, 20mg/kg of body weight daily for 5 days. d) alcohol plus mesoridazine, 20mg/kg of body weight daily for 10 days. 5. Mesoridazine was given orally in a single dose daily at afixed time. The last dose was given one hour and a half before alcohol administration. 6. In all groups, 20% ethanol slowly given in a dose of 5. Oml/kg of body w eight for 5 minutes by intravenous route. 7， All of the blood specimens were obtained by cardiac puncture at both 15 and 45 minutes after alcohol administration. 8. The blood alcohol level was determined by Cavett’s Method. Results 1. Alcohol plus mesoridazine, lOmg/kg of body weight daily for 5 days. Mesoridazine did not change the blood alcohol level significantly at both 15 and 45 minutes after alcoho adm inistration ( P > 0 .05). 2. Alcohol plus mesoridazine, 10mg/kg of body weight daily for 10 days. In this group, there was no significant change in the blood level at both 15 and 45 minuses after alcohol administration ( P > 0 .05). 3. Alcohol plus mesoridazine, 20mg/kg of body weight daily for 5 days. In this group, mesoridazine elevated the blood alcohol level significantly at both 15 ( P < 0 .01) and 45 (P < 0 .001) minutes after alcohol administration. 4. Alcohol plus mesoridazine, 20mg/kg of body weight daily for 10 days. In this group, mesoridazine elevated the blood alcohol level significantly at both 15 (P < 0 .01) and 45 ( P < 0 .02) minutes after alcohol administration. Conclusion 1. Mesoridazine when adm inistered orally in a dose of 10mg/kg of body weight daily for 5 or 10 days, did not changed th e blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. 2. Mesoridazine when administered orally in a dose of 20mg/kg of body weight daily for 5 or 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration.
서 론
실험재료 및 실험방법
실험 결과
고 찰
결 론
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