전기충격요법에 의한 Prolactin과 Growth hormone의 변화

PROLACTIN AND GROWTH HORMONE RESPONSE TO ELECTROCONVULSIVE THERAPY

This study measured serum prolactin and growth hormone concentrations before and after electric convulsive therapy by radio-immuno assay technique using kit of hPRL and hGH for the evaluation of neurophysiological effect of E .C .T . Subjects were consisted of 13 schizophrenics and one case of involutional depression, (7 male, 7 female) (meanage. 24.4， range 18-49 yrs ). Through out the course of E .C .T . th e subject were received chlorpromazine before and durin g treatment period (mean daily dosage; 450mg,. range 300-800mg) There sults were as follows 1. Compared with pre -treatment concentrations,. there was significanty in crease in serum prolactin after E .C .T . in the both male and female subjects, and more predominant in the male subjects. (p 〈0.1, P C .01) 2. The growth hormone response to E.C.T.-appeared to in crease only in the male subjects when compared with its level before E .C .T . (p< &#8226;0 1 ) 3. Throughout 4 times treatment period, the pre -treatment concentrations remained around the basal concentration of prolactin recorded in the first day treatment. Based on the above mentioned findings, it is assumed that then europhysiological response to the E .C .T . such as the in creased prolactin and growth hormone maybe due to the discharges in hypoth alamic neurons