Dibenzepine is a new dibenzodizepine derivative with tricyclci chemical configuration. Chemically, it is 10-[2- (dimethylam ino) ethy l]-5, 10-dihydro-5- methy l-ll-H -dibenzo [b,e][l» 4] diazepine-11-one- Hydrochloride, In the clinical investigation, it was found to have moderate anxiolytic and thymoanaleptic action and to be safe drug. It has mild ortransient side effect and good tolerance, even in larger dosage, It shows more rapid drug response, and is suitable to use in outpatient treatment. Many clinicial in vestig ators have suggested that dibenzepine is indicated for depression of endogenous, endoreactive and reactive origin, involutional and organic depression. Also, investigators suggested that any new psychotropic drugs should be tested for its interaction with alcohol, because they might precipitate the risk situation in case of consuming them concurrently. In view of these reports, the author conducted an animal experiment to investigate the effects of dibenzepine on blood alcohol level in rabbits. Material and Method 1. The experimental work was done on mature rabbits of both sexes, weighing about 2 kg. 2. The experimental animals were divided in to two groups： the control anp the experimental group. 3. The control group was given alcohol alone. 4. The experimental group was divided into 4 sub groups： a) alcohol plus dibenzepine, 80mg/kg of body weight daily for 5 days. b) alcohol plus dibenzepine, 80mg /kg of body weight daily for 10 days. c) alcohol plus dibenzepine, 160mg/kg of body weight daiㅣy for 5 days. d) alcohol plus dibenzepine, 160m g/kg of bodjr weight daily for 10 days. 5. Dibenzepine was given orally in a single dose at a fixed time. The last dose was given one hour and a half before alcohol administration. 6. In all groups, 20% ethanol solution was slowly given in a dose of 5 .0 m //kg of body weight for 5 minutes by intravenous route. 7. All of the blood specimens were obtained by cardiac puncture at both 15 and 45 minutes after alcohol administration 8. The determination of blood alcohol level was made by Cavett’s method. Results 1. Alcohol plus dibenzepine, 80mg/kg of body weight daily for 5 days. Dibenzepine did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration (p > 0 . 05). 2. Alcohol plus dibenzepine, 80mg/kg of body weight daily for 10 days. In this group, these was also no significant change in the blood level at both 15 and 45 minutes after alcohol administration (p > 0 . 05). 3. Alcohol plus dibenzapine, 160mg/kg of body weight daily for 5 days. In this group, these was also no significant change in the blood level at both 15 and 45 minutes after alcohol administration (p > 0 . 05). 4. Alcohol plus dibenzepine, 160mg/kg of boey weight daily for 10 days. In th is group, dibenzepine elevated th e blood alcohol level significantly at both 15(p> 0. 02) and 45 ( p < 0 .02) minutes after alcohol administration. Conclusion 1. Dibenzepine when administered orally in a dose of 80mg/kg of body weight dialy for 5 or 10 days, did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol adm inistration. 2. Dibenzepine, when administered orally in a dose of 160mg/kg of body weight daily for 5 days, did not elevate the blood alcohol level significantly at both 15 and 45 minutes after alcohol admin istration. But, dibenzepine, when administered orally in the same dose daily for 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration.
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