In this study, a comparative evaluation on clinical efficacy between parenteral chlorpromazine and serenace？？ for acute psychotics brought to the emergency psychiatric unit was made. Subjects were consisted of 39 cases of psychotics including 21 males, 18 females they were under double-blind procedure given single injections of 50 mgms of chlorpromazine (20 cases) and 5 mgms of serenace？？ (19cases) separately. The effects were evaluated globally for overall effects as well as by the Brief Psychiatric Rating Scale (BPRS) for target signs and symptoms. The results were as follows 1. Of the 20 cases who received chlorpromazine, 17 cases (85%) were noted to be their symptoms under led controlled or partially under controlled. 2. Of the 19 cases who were administered with serenace？？, 11 cases (58%) become under or partially under controlled while 6 cases (32%) shows few signs of response including 2 cases (10%) were noted to be even worse. 3. Results of BPRS evaluation was applied to them 60 min. after the injection showed the reduction of the total mean BPRS scores for the signs and symptoms. When compared the two group on the reduction chlorpromazine group was significantly remarkable than serenace？？ group. 4. Covariant analysis of the data for 60 min. after the injections chlorpromazine was also noted to be significantly superior than serenace？？ partially for the control of somatic coecern, conceptual disorganization and unusual thought content. Results of the above mention comparison suggests that chlorpromazine were felt to be the drug of choice in psychiatric emergencies requiring the use of an antipsychotic agent. Serenace？髥？ Haloperidol
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