Bromazepam이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

EFFECTS OF BROMAZEPAM ON BLOOD ALCOHOL LEVEL IN RABBITS

Bromazepam is one of the new benzodiazepine antianxiety agents, Chemically, it is 7-bromo-5- (2-pyridl)- 2 H-l. 4-benzodiazepine- 2 (1 H)-one and contains bromine in the structure. In the animal experiments, it was found to have taming, muscle relaxing and anticonvulsive effect and many clinical investigators have suggested that bromazepam is a potent antianxiety drug with little side effects. Investigators suggested that any new psychotrophic drugs should be tested for its interaction with alcohol, because they might precipitate the ritk situation in case of consuming them concurrently. In view of these reports, the author concucted an animal experiment to investigate the effects of bromazepam on the blood alcohol level in rabbits. Summany of the results are as follows: 1. In the group of alcohol plus bromazepam 3mg/kg of body weight for 5 days, bromazepam significantly elevated the blood alcohol level at both 15 (p < 0 .01) and 45 minutes (p < 0 .05) after alcohol administration. 2. In the group of alcohol plus bromazepam 3mg/kg of body weight for 10 days, bromazepam significantly elevated the blood alcohol level at both 16 (p<0.01) and 45 minutes (p < 0 .01) after alcohol administration. 3. In the group of alcohol plus bromazepam 6 mg/kg of body weight for 5 days, bromazepam significantly elevated the blood alcohol level at both 15 (p<0. 001) and 45 minutes (p < 0 .01) after alcohol administration. &#171; 4. In the group of alcohol plus bromazepam 6mg/kg of body weight for 10 days, bromazepam significantly elevated the blood alcohol level at both 15 (p < 0 .01) and 45 minutes (p < 0 .01) after alcohol administration. Conclusion Bromazepam, when administered orally in a dosage of 3mg/kg of body weight daily for 5 days or 10 days, it elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. When given in dose of 6mg/kg daily for 5 days or 10 days, it elevated alcohol more significantly at both 15 and 45 minutes after alcohol administration.