Desipramine이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

EFFCTS OF DESIPRAMINE ON BLOOD ALCOHOL LEVEL IN RABBITS

Desipramine is the monomethyl analogue of imipramine and is introduced as a potent antidepressant agent of rapid action. Most recent reports of desiipramine on depressed patients indicate an effectiveness similar to imipramine. Investigators suggested that any new psychotropic drugs should be tested for its interaction with alcohol because they might precipitate the risk situation in case of consuming them concurrently. In view of these reports, the author conducted an animal experiment to investgate the effects of desipramine on blood alcohol level in rabbits. Summary of the results are as follows； 1. Alcohol plus desipramine, 25mg/kg of body weight for 5 days. Desipramine did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration( P > 0 .05). 2. Alcohol plus desipramine, 25mg/kg of body weight for 10 days. In this group, these was also no significant change in the blood level at both 15 and 45 minutes after alcohol admini stration (P〉0.05). 3. Alcohol plus desipramine, 50mg/kg of body weight for 5 days. In this group,, desipramine elevated the blood alcohol level significantly at 15 minutes after alcohol administration ( P < 0 .02), while there was no significant change in the blood alcohol level at 45 minutes after alcohol administration (P > 0 .05). 4. Alcohol plus desipramine, 50mg/kg of body weight for 10 days. In this group, desipramine elevated the blood alcohol level significantly at both 15 (P<0.001) and 45 ( P < 0 .02) minutes after alcohol administration. Comparing these results of desipramine, the length of duration administering this drug and its dosage seemed to attribute to the elevation of the blood level of alcohol in rabbits. Conclusion 1. Desipramine when administered orally in a dose of 25mg/kg of body weight daily for 5 or 10 days, did not elevate the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. 2. Desipramine when administered orally in a dose of 50mg/kg of body weight daily for 5 days, elevated the blood alcohol level significantly at 15 minutes after alcohol administration, while there was no significant change in the blcod alcohol level at 45 minutes after alcohol administration. But, desipramine when administered orally in the same dose daily for 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration.