Medazepam 및 Cloxazolam 이 가토혈중 주정 농도에 미치는 영양에 관한 실험적 연구

EFFECTS OF MEDAZEPAM AND CLOXAZOLAM ON BLOOD ALCOHOL LEVEL IN RABBITS

Medazepam is a diazepam analogue with a 2-ketone omitted, and is used as an antianxiety agent. The drug shows the characteristic taming effect, muscle relaxant and anticonvulsant properties with minimal side effects and low toxicity. The pharmacodynamic aspects of the drug indicated rapid onset of absorption and rapid biotransformation of oral medazepam in men and dogs, with little accumulation in the plasma. It is also found that diazepam is an important metabolite of medazepam in rats and men, showing a major potency in clinical actions. Cloxazolam is a newer member of the benzodiazepine derivatives, which possess considerable calming effects. It is suggested that the potentiation of alcohol by some psychotropic drugs may, among other things, increase the risk of traffic accidents. Hence, it is necessary to test all psychotropic drugs for their interaction with alcohol. It has been recently reported that many psychotropic drugs including chlorpromazine and lithium, elevated the blood alcohol level in rabbits. In view of these findings, the author conducted an animal experiment to investigate the effect of medazepam and cloxazolam on blood level of alcohol in rabbits