正常人 및 抗精神藥物 服用者의 血獎 및 赤血球 Lithium 濃度에 關한 實驗的 硏究

EXPERIMENTAL STUDY OF PLASMA AND ERYTHROCYTE LITHIUM CONCENTRATIONS IN NORMAL PERSON AND PHENOTHIAZINE TREATED PSYCHOTICS

In order to measure the optimum dosage of lithium maintenance therapy, many reports emphasize the need for measuring not only serum lithium level but erythrocyte lithium concentration. The authors studied plasma and erythrocytelithium concentrations in normal adults without other medication and psychotics under antipsychoticdrug treatment. The results were as follows: 1. The plasma lithium level of normal malewas lower than that of normal female but no difference in excretion rate. (Fig. 1) 2. Maximum erythrocyte concentration was noted 4 hours after lithium administration in normal1 male, a delay of one to two hours compared to normal female group. (Fig. 2) 3. The lithium absorption rate of psychotic male was slower than that of normal male group. In normal male the maximum plasma concentration was noted 4hrs. after lithium administration, while that of the psychotic male was higher 6hr. after the administration. No difference was noted in erythrocyte concentration between the two groups. (Fig. 3) 4. There were no differences in the absorption rate and excretion rate between psychotic female： and normal female groups. (Fig. 4)