In 1962, Sulser et al. first demonstrated that the antidepressant action of amitriptyline is mediated through a metabolic product, desmethylamitriptyMne (nortriptyline). And nortriptyline was synthesized by Dr. H. Spiegelberg and Dr.G. Rey-Bellet. Thereafter numerous studies have indicated that nortriptyline is effective in the endogenous depression. Since Hammer et a l. , in 1967, found that an apparent steady-state plasma level is achieved by repetitive oral administration of nortriptyline at fixed intervals, the enormous studies of the met- ； abolism of nortriptyline have been done. Alexanderson et a l. , in 1969, performed the pharmacokinetic studies with nortriptyline in 78 twins, and it is found that nortriptyline kinetics in man is under the polygenic control. Lawton and Cahn had suggested that any new psychotropic drugs should be tested for its intera- ction with alcohol, because they had been shown to increase the dangers of consuming alcoholic beverage. Recently it has been reported that various psychotropic and antidepressant drugs elevated the blood alcohol level in rabbits. In view of these reports, the author conducted an animal experiment to investigate the effects of nortriptyline on Tblood alcohol level in rabbits
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