Eleven cases whom initially diagnosed as schizoaffective schizophrenia were followed up over two years for the purpose of evaluating the later fate of the course, and considerable problems concerning schizoaffective schizophrenia as a disease -entity and diagnostic orientation of it were discussed with the previous researches. Among the 11 cases, 4 were being become obviously manic depressive; one, typically schizophrenic； whereas one remained schizoaffective and other 5 cases maintained normal life. It is likely that, when evaluating the course longitudinally, the schizoaffective schizophrenia has no its constant clinical feature but reveals some transient symptom complex, and there is no evidence of changing clinical entity perse according to the time passing. It is rather possible to assume that considerable thinking disorders which seen at the early state of manic depressive illness especially of acute mania, delirious mania or stuporous depression may contribute to diagnostic confusion, whereas strong affective symptoms of early stage of schizophrenia may give a cue in diagnosing schizoaffective schizophrenia.