양성 및 음성 증상 정신분열병 환자에서 혈장 Dopamine-P-hydroxylase 활성도에 관한 연구

Plasma Dopamine-P-hydroxylase Activities in Positive and N ^ative Symptom Schizophrenia

The authors investigated the relationship between plasma D BH activities and positive/negative symptoms o f schizophrenia as proposed by Crow s two syndrome hypothesis and also the changes in the plasma DBH activities during 6 weeks o f antipsychotic treatment. The subjects were D SM -III-R schizophrenic or provisional schizophreniform patients(N =25) who were drug free at least for 4 weeks. Plasma DBH activities were measured with clinical symptom assessment repeatedly before(N =25) and during antipsychotic treatment(N二 15). Clinical symptoms were assessed with Positive and Negative Syndrome Scale (PANSS) and plasma DBH activites were assayed by modified Molinoff radioenzymatic method. The plasma DBH activities were found to be lower significantly in negative symptom schizophrenics compared with normal controls. This result suggests that plasma DBH activity may be a useful biological marker to delineate negative symptom subgroup of schizophrenia. It also supports the hypothesis that negative symptom subgroup of schizophrenia may be associated with decreased noradrenergic neurotransmission. The plasma D BH activities decreased after 6 weeks of antipsychotic treatment in positive symptom subgroup o f schizophrenia but not in negative symptom subgroup of schizophrenia. However the changes in plasma DBH activities after the antipsychotic treatment were not significantly different between positive and negative symptom subgroup. And also the changes in clinical symptoms did not correlate with the changes in the plasma DBH activities. Based on these findings, the changes in plasma DBH activities were speculated as not to reflect the changes in clinical symptoms but as the effects of antipsychotic drugs