慢性精神分裂病 患者에서 電氣衝擊療法이 腦脊髓液 5-HT와 5-HIAA 濃度에 미치는 影響에 관한 研究

The Effect of Electroconvulsive Therapy on the Cerebrospinal Fluid 5-HT and 5-HIAA Concentrations in the Chronic Treatment-Resistant Schizophrenia

The effect of a series of ECT treatments on the C SF 5-HT and 5-HIAA concentrations was studied in the 10 patients suffering from chronic treatment-resistant schizophrenia. The clinical improvement of the patients was assessed with BPRS weekly. Total BPRS scores signiflcantiy decreased after a series of ECT treatments. A nd positive, negative, thinking disturbance, withdrawal/retardation and hostility/suspiciousness symptom subscale scores were also decreased significantly after ECT treatments. But anxiety/depression symptom subscale score did not show statistically significant change. The CSF 5-HT concentrations significantly decreased after a series of ECTs. But the CSF 5-HIAA concentrations showed a trend to decrease which was not statistically significant. Percentile improvement on total BPRS score was positively correlated with pre-ECT concentration of CSF 5-HT showed the better clinical improvement. And percentile improvement on total BPRS scores showed significant negative correlation with change in the concentration of 5-HT after ECT treatments. These results suggest that ECT may be effective in the treatm ent of treatment-resistant chomic schizophrenia and, although it’s mechanism is still unknown, may affect the central serotonergic system in schizophrenics, which may be related to the clinical improvement after a series of ECTs.