24시간 혈중농도와 신배설률을 이용한 리툼 치료량 예측법의 평가비교

A Comparison Between the 24 Hour Serum Level and the Renal Clearance to Predict Therapeutic Lithium Dose

Cooper’s method using 24 hour serum lithium level and Normans method using renal lithium clearance after a single loading dose were compared to determine which predicted therapeutic lithium dose better. The author concluded the Norman’s method was superior after evaluating the accuracy, the rapidity, and the utility of the two methods. And the author suggest the availabilty of the predicting methods to overcome the limitations of lithium therapy, such as the Harrow range of therapeutic level, the time-consumption reaching therapeutic level, and the individual variation of therapeutic dose. The summary of results were as follows: 1) In Cooper’s method, the objects included in the acute therapeutic level, 0.80〜 1.20mEq/l， were only 10 of 19 objects after taking prdeicted lithium dose. 2) In Norman’s method, the objects included in the acute therapeutic level were all of 19 objects, and the actual serum lithium level, 0.80〜 1.15mEq/K were predicted with average error ±4.89%.