The neurophysiological basis of psychiatric disorders is, for the most part unknown. Though the relationship between the dysfunction of basal ganglia and psychiatric disorders is also unknown, the possibility is confirmed by many researchers. The suggestion is that the basal ganglia, acting as an active sensory modulating station, maintain the normal flow of information processing. The dysfunction of the basal ganglia have been implicated in many psychiatric symptoms such as mood disturbance, delusion, hallucination, motor disorder and hypersensitivity. Recently many brain imaging studies, using Positron emission tomography (PET), Single photon emission computed tomography(SPECT) and Magnetic resonance imaging(MRI) are being done eagerly trying to confirm the funtional and anatomical changes of various brain region including basal ganglia in vivo. The authors experienced two cases of psychiatric inpatients with basal ganglia lesion detected in computed tomography (CT) scan incidentaly. One showed major depression like symptoms and the other showed schizophrenia-like symptoms. The authors reported two cases with literature review related to basal banglia in psychiatry.
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