Benztropine Mesylate가 Haloperidol 타액농도에 미치는 영향에 대한 연구

The Effect of Benztropine Mesylate on Haloperidol Saliva Level

Nineteen patients with schizophrenia by the DSM -III-R were administrated with only haloperidol in the first period. And the second period began after extrapyramidal symptoms developed, in this period they were administrated with haloperidol and benztropine concomittantly. At the third period after withdrawal of benztropine, they were administrated with only haloperidol. For the purpose of evaluating the effect of benztropine mesylate on the haloperidol saliva level, the authors measured the haloperidol saliva level, the reduced haloperidol saliva level and the ratio of the reduced haloperidol saliva level/the haloperidol saliva level at the seperated adm inistration period. The results are as follows; 1) Though the haloperidol saliva level of the single administration period of haloperidol was higher than that of other two periods, there was no statistically significant change. 2 ) The reduced haloperidol saliva level had no statistically significant change among three periods. 3 ) The reduced haloperidol saliva level/the haloperidol saliva level ratio had no statistically significant change among three periods. The authors concluded that the benztropine mesylate had no significant effect on the haloperidol saliva level in this study