만성 정신분열증 환자의 음성증상과 다른 증상과의 상호 관계에 관한 연구 ᅳ 음성증상과 우울증상, 추체외로증상과의 관계를 중심으로 ㅡ

A Study on Relationship among Negative Symptoms and Other Symptoms of Chronic Schizophrenics — Mainly on Relationship among Negative Symptoms, Depressive Symptoms, and Extrapyramidal Symptoms —

For an approach to the pathophysiology of negative symptoms through their classification, the authors evaluated the relationship among negative symptoms, positive symptoms, depressive symptoms and extrapyramidal symptoms, and the change of each symptom . The subjects of study were 105 chronic schizophrenics who had been admitted to the Seoul National Mental Hospital from March, 1990 to December, 1990 and negative symptoms were measured by SANS, postive symptoms by SAPS, depressive symptoms by HDS and extrapyramidal symptoms by EPSRS on admission and 4 weeks later. The results were as follow ; 1) There was no significant correlation between negative symptoms and previous course of illnessCnumber of previous hospitalization, duration of previous hospitalization, age at onset and months since onset) on admission and 4 weeks later. 2) There was significant correlation between negative symptoms and depressive symptoms (P 〈0.01), and between negative symptoms and extrapyramidal symptoms(P〈0X)1)，and depressive symptoms and extrapyramidal symptoms(P < 0 .0 1 ) showed significant correlation only 4 weeks later. 3) Negative symptoms, positive symptoms and depressive symptoms were significantly improved after 4weeks treatment (all P〈0.01), whereas extrapyramidal symptoms were not significantly changed. 4 ) For the correlation of subscales, working capacity and loss of interest of HDS , other items of HDS and rigidity of EPSRS were significantly correlated with all subscales of SANS on admission and 4 weeks later(P < 0 .0 1 , or P < 0 .0 5 ). 5) For the change of each subscale after 4 weeks treatment there was significant improvement in all subscales of SANS and SAPS (all P < 0 .0 1 ), and in insomnia, working capacity and loss of interest and other items of HDS (P< 0 .0 1 , P < 0.0 1 , P< 0.05), whereas no in all subscales of EPSRS. These findings suggest that there are negative symptoms due to depressive symptoms and extrapyramidal symptoms, and that improvement of negative symptoms after 4 weeks treatment is more associated with that of depressive symptoms rather than that of extrapyramidal symptoms.