정상인에게 Nortriptyline 경구 투여가 혈장 3-Methoxy-4-Hydroxyphenethyleneglycol 농도에 미치는 영향

The Effect of Single Oral Dose of Nortriptyline on Plasma 3-Methoxy-4-Hydroxyphenethylenglycol in Healthy Subjects

Ths purpose of this study was to examine the pharmacological effect of nortriptyline, the secondary amine antidepressant, on noradrenergic system from the point of pharmacokinetics and pharmacodynamics. Twelve healthy male volunteers took single dose of nortriptyline (20mg, 50mg). Plasma nortriptyine and M H P G concentration were measured periodically in 0, 1, 3，5, 8，12, 24，28，32，48 hours after then by HPLC method. Summary of results were as follows : 1) Plasma peak levels of nortriptyline were attained at about 5 hours after administration of the drug. Area under the plama concentraion time curve(AUC) was 297.7士 61.3hr ng/ml (20mg，N = 6 ) , 678土 102.4 hr ng/ml (50mg, N = 6) respectively, and showed proportional relationship with oral dose. 2) Plasma MHPG level was significantly decreased and maintained that condition from one to 48 hours, Reduction of MHPG level was largest in 8-12hours(up to 50O . 3) MHPG decrease showed slight delay compared with each nortriptyline concentration.