태음인 정상-과체중군과 비만군의 식이관련지표 및 식사 전후 Gut Hormone 비교연구

The Comparisons of Eating-Related Index and Pre- and Post-Prandial Gut Hormone Patterns between Normal-Overweight and Obese Subjects of Taeemin

The purpose of this studay was to compare the eating-related index and the patterns of pre- and post-prandial gut hormone level in normal-overweight and obese subjects of Taeemin population. Methods: We enrolled healthy male participants who were diagnosed with Taeeumin by Sasang Constitutional diagnosis and who were normal-overweight (18.5 kg/m2≤body mass index [BMI)< 25 kg/m2) or obese (25.0 kg/m2≤BMI<30 kg/m2). Eating behavior and gastrointestinal problems were assessed by using standardized scale. Subjective appetite ratings using visual analogue scales and the profiling of serum levels of ghrelin and peptide YY (PYY) were assessed before and after a standard meal (6 time points: 30 minutes pre-prandial, immediately before meal, 15, 30, 60, and 120 minutes post-prandial). Results: Tewnty two healthy Taeeumin people classified as normal-overweight group or obese group are the final subjects. External eating score of Dutch eating behavior questionaire scores is higher in normal-overweight group than in obese group. The variations of subjective appetite ratings in obese group are smaller than in normal-overweight group. The pattern of ghrelin in normal-overweight group shows a high peak at 30 minutes post-prandial point, which is contrary to existing studies. The pattern of PYY in obese group decreases from 15 minutes post-prandial point and shows lower peak level, whereas in normal-overweight group shows increasing tendency from pre-prandial point until 30 minutes post-prandial point. Conclusions: There are differences in the eating-related index and the gut hormone patterns related to obesity.