座攀性 腦-電氣衝擊에 의한 생쥐 視床下部 및 腦幹의 Monoamine 代謝의 變動에 관한 研究

Effects of Single and Repeated Electroconvulsive Shock on the Hypothalamus and Brain Stem Contents of Monoamine Metabolites in Mice

Male ICR mice ranging from 15g to 20g were given a single ECS( 1-ECS * 13mA, lsec, lOOcps) daily or on alternate days for 10 days(5-ECS). The contents of monoamine metabolites in the hypothalamus and the brain stem(BS) were measured 10，30, and 60 min after ECS-administration as well as before ECS. Contents of monoamine metabolites in the HT and the BS, such as 5-HIAA, MHPG, DOPAC and HVA increased rapidly after 1-ECS or 5-ECS and then came down to the pre-ECS values. However, their increases induced by 5-ECS were significantly smaller than those by 1- ECS except the tedious increase of the hypothalamic HAV content. 5-HIAA and MHPG in the HT decrease significantly by the 4th administration of ECS in the course of the 5-ECS treatment. These results suggest that the repeated treatment of ECS may decrease the turnover rates of serotonin and noradrenaline in the hypothalamus