不眠에 對한 8ᅳChloro-6-Phenyl-4H-s-Triazolo〔4.3ᅳa〕 〔1.4〕 Benzodiazepine 의 効果에 關한 臨床硏究

THE EFFECT OF 8-CHLORO-8-PHENYL-4H-S-TRIAZOLO〔4 -3 -a ]〔1-4〕 BENZODIAZEPIN E ON INSOMNIA : A DOUBLE BLIND CHINICAL STUDY

In this studyi authors Examined the hypnotizing effect of Estazolam on patients in I. P. D & 0. P.D. who visited with the chief complaint of insomnia The number of patients selected for this study were 156. They were consisted of 78 neurotics other than depression, 66 depressive patients and 12 mild psychotic patients. Authors applied the double blind clinical method with Estazolam and placebo to the patients. They visited OPD & IPD of Psychiatric department of SNUH (Seoul National University Hospital) from October-1, 1975 to March-31, 1976. The results were as follows: 1. Estazolam had the highest sedating effect to the patients with mild psychosis and the least effect to the neurotics except depression. 2. Total duration of sleep increased approximately 20-30 minutes. 3. No difference was noticed between 2mg and 3mg administrated groups. 4. It seemed that Estazolam had no influencoe on REM sleep pattern (frequency of dream). 5. It was a most effective method to use Estazolam combined with other specific drugs to the patient who had suffered from insemnia for a long period.