Following the first report of a lithium maintenance therapy on September 1975, the authors observed 30 cases of maic-depressive psychosis who is receiving lithium maintenance therapy more than One year in the Department of Neuropsychiatry；Korea University. We studied the frequency and duration of manic-depressive episodes before and during lithium maintenance therapy and effective serum lithium level. The result as follows: 1. Averagfe age of onset was 23.4. 2. Averagfe frequency manic^dfepressive episodea fell from 3.1 to 1.4 and average duration fell from 9.5±3.5 to 4.5±2.6 weeks in similar period. The result demonstrate very strong evidence of lithium for a preventive effect of manic-depressive episodes and reducing duration of episodes. 3. The effective serum lithium level was 0.64土 0 .17mEq/l in 800 to 1, 500mg daily dosage
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대상 및 방법
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