From our advantage point as clinicians with a working knowledge of basic pharmacologic research, we thought that certain commonly accepted clinical observations would be of interest to the clinician and psychopharmacologist. The clinical observation that antipsychotic and antidepressant drugs may exert their respective therapeutic effects independently when combination therapy in patients disclosing mixed symptomatology seems to have important psychopharmacological implications. In the current psychopharmacologic concepts, this clinical observation shows that suggesting the dopamine system is an important factor to the etiology and therapy of schizophrenia and the norepinephrine system is an important factor to the etiology and therapy of depressive illness
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