베타 2-아드레날린 수용체의 유전자 변이형이 비만도에 미치는 영향

Effects of β2-Adrenergic Receptor Polym orphism on Obesity

Objectives: The lipolytic effects of catecholamines in adipose tissue are mediated by members of adrenergic receptors. This study was conducted to examine the effects of β2-AR Gln27Glu (Q27E) polymorphism on obesity indices and risk among obesity clinic patients. Methods: 532 subjects, 38 men and 494 women, who attended a weight loss program in a local obesity clinic were analyzed. Height, weight, BMI, WHR and obesity index were measured or calculated. Body composition was measured by bio-impedance analysis. Genotype of β2-AR polymorphism in codon 27 was analyzed by PCR-RFLP method. Serum concentrations of fasting glucose, total and HDL cholesterol, and triglyceride were determined by autobiochemical analyzer. Results: The Genotype distributions of β2-AR gene were QQ type 81.3%, QE type 17.9% and EE type 8%. Therefore, the frequency of E allele of β2-AR gene was 0.170 in the total subjects. The frequency of the β2-AR variant genotype(QE+EE) was significantly higher in obese group(BMI>25) compared with non-obese group(p=0.027). Weight was significantly higher in variant(QE+EE) type compared with normal(QQ) type in total subjects(p=0.001), male(p=0.022) and female(p=0.013). BMI, obesity index and WHR were also significantly higher in QE+EE type. Body fat mass was significantly higher in QE+EE type in total subjects(p=0.005) and female(p=0.027). When forward stepwise regression analysis was used to create a model of risk predictors of obesity(BMI>25), QE+EE type of β2-AR gene was found to be a significant risk factor for obesity (p=0.042, ORs 1.597). Conclusions: QE+EE genotype of β2-AR was associated with increased obesity indices and might be a significant risk factor for obesity.