D.D.S 藥物中毒으로 因한 急性精神病 一例

A CASE OF ACUTE PSYCHOSIS DUE TO D. D. S INTOXICATION

DDS, a derivatives of D. D’-diaminophenyl sulfate， was first reported by Buttle and Fourneau in 1937, and had been used as an antibiotics until 1943, when Cowdrey and Ruangsiri proved it to be most effective to the Leprosy. Reported as its side effects are hemolysis, methemoglobinemia, hematuria, cyanosis, vomiting, nervousness, disturbance of memory and orientation, and acute psychotic symptoms when used in a large doses. The authors have also observed a case manifesting acute toxic and psychotic symtoms due to misuse of a large doses of DDS, was improved by administration of methylene blue, 250 mg combined with ascorbic acid, 150 mg per day for 4 days.