정신분열병 환자에서 지연성 운동장애와 양성，음성 증후군과의 관련성

The Relationship of Tardive Dyskinesia with Positive and Negative Syndromes in Schizophrenic Patients

Objects : The authors investigated the association between tardive dyskinesia and positive and negative syndrome in schizophrenia. Method : Eighty-two inpatients who satisfied DSM -III-R criteria for schizophrenia and were given antipsychotic medication for more than two years were rated for positive and negative syndromes with the Postive and Negative Syndrome Scale(PANSS) as well as cognitive state with the Mini-Mental State Examination(MMSE). The subjects comprised 41 patients meeting Schooler & Kanes criteria for tardive dyskinesia and 41 age- & gender-matched control patients without tardive dyskinesia. Results ： Statistically significant associations were found between tardive dyskinesia and negative syndrome, especially in female schizophrenic patients, but there was no association between tardive dyskinesia and cognitive impairment. Patients with negative syndrome had a lower score in MMSE and a higher score in general psychopathology scale of PANSS with statistical significance than those with positive syndrome and intermediate type. Conclusion ： Tardive dyskinesia was associated with negative syndrome in schizophrenia and it was suggested that there may be a sexual difference in the etiology of tardive dyskinesia and negative syndrome. Schizophrenics with negative syndrome had more severe cognitive impairment and psychopathology compared to those with positive syndrome or intermediate type, possibly due to their early onset and longer duration of illness