We examined 423 chronic psychiatric inpatients who had a history of at least three months’ total cumulative neuroleptic exposure for tardive dyskinesia(TD). In this study, we used both structured scales of dyskinesia and videotape recording. Demographic, clinical, and drug history data were collected to assess whether any of these factors was significantly associated with TD. The authors found a high prevalence(51.3%) of TD. The subjects over age 60 are significantly associated with the presence of TD. Female sex, duration of hospitalization, length of neuroleptic treatment, and exposure to antiparkinsonian agents also were related to increased risk. However, there was no significant relationship between the presence of TD and other factors including psychiatric diagnosis, daily dosage of neuroleptics, or history of alcohol, smoking, electroconvulsive therapy, head trauma. Interestingly, the history of tricyclic antidepressant medication was associated with decreased prevalence. Further work is needed to perform well-controlled prospective study.
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