The authors measured the total serum cholesterol values in 22 patients with major depression and compared the values in the patients with pain and those without pain. The results were as follows ; 1) The serum total cholesterol was significantly higher in the depressives with pain than in those w ithout pain. W hen the subjects were limited to the females, the same trend was seen. 2) A positive correlation was seen between pain symptom and serum total cholesterol. W hen the subjects were limited to the depressives with pain, the same positive correlation was shown. Consequently, we think that 5-HT dysfunction is related to a subset of depressives with pain and with higher serum total cholesterol.
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