Chlorpromazine이 전기경련 충격에 의한 흰쥐 대뇌피질 c-fos 및 jun B 발현에 미치는 영향

Effects of Chlorpromazine on c-fos and jun B Induced by Electroconvulsive Shock in Rat Cerebral Cortex

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D2 blockade is traditionally considered to be the major mechanism of action of antipsychotics. But most antipsychotics have many other pharmacologic properties. This led us to investigate the mechanisms of action of antipsychotics from the viewpoint other than the blockade o f D 2. We have chosen the induction of c-fos and jun B as a marker of the activity of brain cells and investigated the effect of chlorpromazine(CPZ) on the induction of c-fos and ju n B by electroconvulsive shock(ECS) in rat cerebral cortex. CPZ did not affect the induction of c-fos and ju n B by ECS at the dose of lO mg /k g . But at 30 mg /kg , CPZ attenuated and retarded the induction of c-fos and ju n B by ECS. Chronic treatment with C P Z (21 consecutive days, lO mg /kg /day ) did not altered the patterns and peak amount of inductions. Considering D 2 blocking ability of CPZ , CPZ perse would induce c-fos and ju n B or in crease the induction of c-fos and ju n B by ECS. But our results show the contrary. Hence, there seems to be other actions of C P Z than the blocking of D2 receptor, such as the in hibition of calmodulin and protein kinases, on the signal transduction system of the brain.