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Corpus Callosum Dimensions Measured by Magnetic Resonance Imaging in Schizophrenia

In order to evaluate the morphological change of corpus callosum which may play a major role in abnormal neural transfer of information between two cerebral hemisphres in schizophrenics, the authors measured the size of corpus callosum of the 25 schizophrenic patients who were diagnosed by DSM-III-R(1987), visited at department o f neuropsychiatry, Chun-Ang u n iversity hospital (Young San, Phildong) from October 1993 to March 1994，by using the midline saggital slice of M R I. These results were compared with the size of corpus callosum o f 25 neurotic patients who had visited at Chung-Ang university hospital. The results were as follows : 1) Schizophrenic patients had larger total callosal area, genu area, splenium area than control group. 2) Female schizophrenic patients had significantly larger splenium area and higher ratio of splenium to total callosal area than the female control group. Male schizophrenic patients had significantly larger total callosal and genu area than the male control group. 3) Although male schizophrenic patients had sim illar size of corpus callosum with female schizophrenics, the male control group had larger splenium, thicker anterior callosal width and higher ratio of splenium to total callosal area than the female control group.