Objects : In this study the authors tried to elucidate any relationship between schizophrenia and the im mune function by measuring the serum im munoglobulin level in schizophrenic patients and observing the changes of the serum im munoglobulin in the clinical course and type. Methods • The subjects of this study were 28 schizophrenics who had been admitted to the Neuropsychiatric Department of Chung Ang University Hospital and a private neuropsychiatry clinic and 20 healthy young /adults were recruited for control. On admission and after one month later, the serum im m unoglobulin concentration and PANSS were serially evaluated. The collected data were analysed through the SPSS program. Applied statistic methods were Mann-Whitney U test, Kruskal-Wallis test and Pearson’s correlation. Results : 1) Only Ig A concentration of schizophrenic patients was significantly higher than that of normal controls. 2) There was no significant difference between positive and negative schizophrenic patients, but both positive and negative schizophrenic patients showed a significantly higher concentration of Ig A than controls. 3) Age was positively correlated with Ig A concentration in schizophrenic patients. 4) Each Ig concentration of schizophrenics tended to decline on the clinical course, but it was not statistically significant 5) In schizophrenic patients, each Ig concentration at admission was not related to degree of improvement of psychotic symptoms and dosage of antipsychotic medication had no in fluence on each Ig concentration. Conslusion In summary, it was postulated that immune system abnormality contributed to pathology of schizophrenia. But im mune system abnormalities might be due to altered stress response in schizophrenia. Therefore further research for relationship of stress-schizophreniaim mune system is needed to support these interpretations. Also between positive and negative schizophrenia, im mune function or stress response showed no difference
서 론
대상 및 방법
결 과
고 찰
결 론
참고문헌