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KCI등재 학술저널

腦影像術을 通한 腦의 形態學的 分析 方法論 硏究

Methods for the Quantitative Morphologic Analysis of Cross-Sectional B rain Images

Objects : For the quantification and topographic analysis of cross-sectional brain images, Methods : The authors developed a planimetric method with boundary tracing, image digitizing and pixel counting. And each axial brain image was splitted into unit sectors of equal area, using polar coordinates as the frame of reference with its origin at the center of the symmetry line of the brain image. The sectors were reconstructed on a radial coordinates so as to represent the topographic profiles o f the C SF spaces. A M R I study with these methods was performed in 26 Alzheimer patients(age, 722土 7.0) according to N IN C D S-A D R D A criteria and 22 normal control subjects(age, 71.5±5.4). Results : Alzheimer patients showed greater ventricular and cerebral (cortical and ventricular) atrophy than control subjects(p〈0.05). In healthy volunteers, all the cerebral atrophy indices measured exhibited significant correlation with ageCp^O.OOS), but not in Alzheimer patients. Analysis of the topographic profiles o f the Alzheimer and control groups demonstrated that the lateral ventricles of the Alzhiemer group showed more dilatation in all directions and showed accentuated dilatation in frontal and Conclusion : These methods could be useful changes in cross-sectional brain images. occipital horns. in quantifying and characterizing morphologic

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