혈청 Lithium농도와 타액 Lithium농도의 상관성

Correlation between the Concentrations of Serum and Saliva Lithium

Serum and salivary lithium concentrations were measured by atomic absorption spectrophotomerter and both concentration rates were compared for the trial of possible clinical usage of saliva concentration of lithium. The subjects were 27 hospitalized psychotics who had been given fixed dose of lithum over 2 weeks continuously. Salivary gland stimulation was performed with chewing gum. The statistically significant correlation between serum lithium concentration and salivary lithium concentration could be proved using the Student’ s t-test(r=0.767, p<0.000l). From this study, possibility of clinical usage of saliva concentration for lithium mointoring was suggested.