HLA-DR2 陽性 反應을 보인 嗜眠病 1例

A Case of H LA—DR2 —Positive Narcoleptic Patient

The authors experienced a 28 year old male narcoleptic patient who revealed narcoleptic tetrad ; sleep attack, cataplexy, sleep paralysis, and hypnagogic hallucination lasted for about 3 years. The patient has a history of poliomyelitis in early childhood and has sustained head trauma just before the onset of narcolepsy. And also HLA—DR2, DQwl, and DR4 positive reaction was confirmed with the method of microcytotoxicity using Terasaki HLA-ABC and HLA—DR tissure typing trays. Sleep attack was somewhat controlled with methylphenidate and cataplexy with imipramine, and other symptoms were also improved followed by the improvement of sleep attack and cataplexy. With this case report, aspect of biologic etiologies of narcolepsy were reviewed.