알코올 의존 환자에서 갈근이 혈중 알코올 농도와 음주 효과에 미치는 영향

Effect of Radix puerariae on Blood Alcohol Concentration and Alcohol Effects in the Alcoholics

Effect of radix puerariae on blood alcohol concentration and on alcohol effect in alcoholic patients was studied. The subjects were 57 hospitalized male alcoholics recovered from acute intoxication and withdrawal symptoms. They were divided into two groups of 29 subjects of experimental group and 28 control group. The experimental group was administered with 10g/ day of powder of radix puerariae and the control group with mixture of 4g/day of radix glycyrrhizae and 6g/day of flour for 4 weeks, respectively. Before and after treatment of the drugs, blood alcohol concentration, vital signs, and mania rating scale were measured at - 5， 10，30，60，90 and 120 minutes after administration of 25% alcohol at a dose of 6ml/kg b.w.p. o. The results were as follows : 1) Blood alcohol concentration was not changed by four weeks of radix puerariae treatment and no difference in the blood alcohol concentration was noted between the radix puerariae and the control groups. 2) Radix puerariae significantly lowered systolic blood pressures at 10, 30，60 and 90 minutes after alcohol intake and diastolic blood pressures at 10，30，60，90 and 120 minutes after alcohol intake as compared to the corresponding pre-treatment levels. Moreover, before radix puerariae treatment, alcohol-induced elevation of systolic blood pressure was significant at 10 minutes after alcohol intake and that o f diastolic blood pressure was significant at 10，30 and 60 minutes after alcohol intake. But after radix puerariae treatment, such elevation was abolished. 3) Radix puerariae reduced significantly levels o f motor activity at 60 and 90 minutes after alcohol intake and levels of voice at 10，30, 60 and 90 minutes after alcohol intake as compared to the respective pre-treatment levels. Alcohol-induced enhancement of motor activity was significantly increased from 10 minutes after alcohol intake before radix puerariae treatment. But after the drug treatment，it was significantly increased from 60 minutes after alcohol intake. Thus radix puerariae delayed the development of alcohol-induced enhancement of motor activity. 4) No significant differences were noted in the levels of anxiety and depression between the index group and the control, either before or after respective drug treatments. 5) Food intake was not changed during the experimental period in both groups