알쯔하이머병의 말초 생물학적 지표로서 혈청 Alpha-1-antichymotrypsin

Serum Alpha-l-antichymotrypsin Concentration as a Peripheral Biological Marker in Alzheimer’s Disease

Objectives : The authors measured serum alpha-1 -antichymotrypsin(ACT) level to elucidate its possibility to be a peripheral marker in Alzheimer s disease(AD) and to examine its relationship with aging. Methods : The subjects were 19 AD patients(age ： 71.9 土7.6，range : 55 - 89) diagnosed by NINCDS-ADRDA criteria, 8 vascular dementia(VD) patients(age ： 72.5±9.4，range ： 56-85), 32 normal control subjects(age ： 42.4土21.4，range ： 21-82). Serum ACT levels were determined with radial immunodiffusion plates purchased from the Binding Site after 72-hour incubation. Results ： The serum ACT levels of AD patients were not significantly different from those of old control(OC) subjects(age ： 70.9 ±4.6 range ： 66 - 82), but ACT levels of VD patients were significantly higher than those of OC subjects(p〈0.05). And there was significant correlation between ACT levels and age(r=0.5820，p<0.01). Conclusions ： These results suggest that the increment of serum ACT level appears to be associated with the vascular component in dementia patients as well as with normal aging factor. However, its possibility to be a peripheral marker of AD seems to be low