The purpose of this study was to compare the number and percentage of natural killer cell in schizophrenic and major depressive patients with those in normal healthy subjects. 15 Schizophrenic patients, 15 major depressive patients and 16 healthy subjects were included in this study. There was no statistical difference in the age and sex between patients and control subjects. All of these patients were drug-free for at least two weeks before this study. The results of this study were as follows : 1) In schizophrenic patients, the number and percentage of natural killer cell of the group with below-mean score of general psychopathology were significantly lower than those of the group with above-mean score(p〈.05). The number but not the percentage of natural killer cell of the group with below-mean BPRS score was significantly lower than that of the group with above-mean BPRS score(p〈.05). 2) The number of natural killer cell showed statistically negative correlation with general psychopathology score or BPRS score(p<0.05). In conclusion, these findings suggest that the number and percentage of natural killer cell is not significantly changed in schizophrenia and major depressive disorder, but in schizophrenic patients, severe psychopathology in the rating scales is associated with suppression of the number and percentage of natural killer cell
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연구대상 및 연구방법
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