음성증상 정신분열병 환자에서 Haloperidol 단독치료와 Carbamazepine과 Haloperidol, Valproic acid와 Haloperidol 병합치료간의 비교

A Comparison among Haloperidol vs Carbamazepine-Haloperidol vs Valproic Acid-Haloperidol Treatment in Negative Symptom Schizophrenia

The purpose of this study was to compare the clinical effects of carbamazepine and haloperidol vs valproic acid and haloperidol vs haloperidol alone in negative symptom schizophrenia. The subjects of this study consisted of 45 patients with chronic schizophrenia according to DSM-III-R criteria and had predominant negative symptoms evaluated by PANSS. The subjects were divided into 3 groups randomly. Group A was treated with fixed dose of haloperidol combined carbamazepine up to lOOOmg/day, Group B was treated with fixed dose of haloperidol combined valproic acid up to lOOOmg/day and Group C was treated with haloperidol only. During the study, 4 subjects were dropped out because of severe side effects and 1 subject was dropped out because of early discharge. The remained 40 subjects were assessed with BPRS and PANSS negative scale. There was no significant difference among the three groups in total and subscales of BPRS, and negative scale of PANSS. This result did not support that combined treatment with carbamazepine and haloperidol, and with valproic acid and haloperidol could be more effective than treatment with haloperidol alone on negative symptom schizophrenia