Objects : The authors investigated to evaluate the clinical utillity of serum prolactin(PRL) level as a therapeutic index of haloperidol treatment for acute psychotic patients. Methods ： 22 patients(10 males, 12 females) first-onset schizophreniform disorder were studied. Among them 10 male patients baseline PRL levels were compared to those of 11 agematched male volunteers and 11 patients who were treated with oral haloperidᄋ1(4 males, 7 females) were studied by measuring baseline and 4the week levels of serum PRL and haloperidol and administering Positive and Negative Syndrome Scale(PANSS) concurrently. Results ： 1) The serum PRL level of 10 male patients showed no statistical difference from 11 healthy males. Only the patients pre-treatment PANSS negative subscale score had significant correlation with the baseline serum PRL level. 2) Percentage of PANSS score change didn’t show significant correlation with the baseline and 4th-week serum PRL level nor with amount and percentage of serum PRL level change. 3) The total PANSS score decreased significantly after 4 week treatment with haloperidol as well as positive symptoms subscale and general psychopathology(all, p 〈 0.05)，and 4th-week serum PRL level significantly increased(p <0.01) compared with the baseline. 4) The 4th-week plasma haloperidol level didn t show correlation with serum PRL level nor with amount and percentage of serum PRL level change. Conclusions : The findings suggest that serum PRL level has limitation for use as therapeutic index of haloperidol treatment for acute psychotic patients.
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