For the investigation of the effect of long-term continuous ethanol(EOH) administration and EOH withdrawal on the immune response potential and sexual dimorphism in the tumorigenesis induced by 3-Methylcholanthrene(MCA), the frequency of tumor production and the number of tumors per tumor bearing mouse(TBM) in female and male mice were examined. The production of IL-2 and natural killer cell activity(NKCA) of murine splenocyte were also examined. It was found that EOH feeding may suppress IL-2 production and NKCA but may enhance tumor growth, and there was a sexual dimorphism in tumor production in mice. It was also found that EOH withdrawal decreased the number of tumors per TBM, and EOH termination did not reverse the depression of both IL-2 production and NKCA caused by the previous EOH feeding.
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