한국인 정신과 환자의 적혈구 및 혈장내 할로페리돌 농도에 관한 연구

Haloperidol Levels of Rad Blood Cells and Plasma in Korean Psychiatric Patients

The first goal of this study was to search the possibility of RB C being used as an alternative specim en instead of plasma or serum in the therapeutic drug m onitering of haloperidol. The second goal was to find out the relationship o f the ratio betw een RBC haloperidol levels and plasm a levels in 27 Korean psychiatric patients w ho h a d taken haloperidol for 1 to 2 weeks with fixed dose over 30mg. R B C and plasm a sam ples from haloperidol-treated K orean patients were analysed by High Perform ance Liquid Chromato graphy (H P L C ) with ultraviolet detector. The H P L C assay allows sim ultaneous m easurem ent of the reduced metabolite of haloperidol. The results are as follows: 1) Daily haloperidol dosage did not have a staistically significant correlation with concentration levels of plasm a H aloperidol, plasm a reduced haloperidol and R BC reduced haloperidol. 2) Plasma haloperidol levels hada fair correlation with plasm a reduced haloperidol levels(r= 0.468, p < .0 5 ) and the ratio of plasma reduced haloperidol versus plasm a haloperidol levels was 1.49. Plasma haloperidol did not have correlation with RBC reduced haloperidol levels. 3) Plasma reduced haloperidol levels had a good correlation with R B C reduced haloperidol levels(r= 0.485,p < 0 .0 1 ) and the ratio of RBC reduced haloperidol versus plasma reduced ahloperidol was 0.63.