The purpose of this study was to com pare N K cell activity in schizophrenic patients with those in norm al healthy subjects. 53 schizophrenic patients and 49 healthy subjects were included in the study. Of 53 schizophrenic patients, 42 patients h ad been treated with antipsychotic drugs for at least 6 months before the study and 11 patients had been drug free before the study. The results of the study were as follows : 1) Schizophrenic patients showed significantly lower NK cell activity than control subjects did. There was a statistically significant difference between schizophrenic patients and control subjects in N K cell activity(p<0.0001). 2) There was a statistically significant difference in NK cell activity between drug treated group and drug free group(p<0.000l). 3) There was not a statistically significant difference in NK cell activity between drug free group and normal control group (p〉0.05). 4) Sex difference of the N K cell activity was not statistically significant(p〉0.05). 5) Age difference of the N K cell activity was not statistically significant(p>0.05). In conclusion, these findings suggest that NK cell activity is significantly associated with schizophrenia.
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