强迫障碍와 人間組織適合性抗原

Obsessive Compulsive Disorder and Histocompatibility Antigen

A HLA-typing(HLA-A，B, C , D R , D Q ) was conducted on 35 patients diagnosed as obsessive compulsive disorder(OCD) based on the DSM-IH-R criteria for a comparison with HLA of the normal controls. The normal controls consisted of 30 healthy medical students for HLAA, B, C and 136 healthy persons for HLA-DR, DQ. The Tearasaki method was used for HLA-A, B，C and PCR method, for HLA-DR, DQ. The frequencies of HLA for both OCD patients and the normal controls were compared by means of the Gart and Nam statistical analysis method and the Pvalue was corrected by multiplying the tested antigen numbers, to avoid the Type 1 error. When compared with the normal controls, HLA-B60 was found significantly high in frequencies among OCD patients(p<C.0.05)，with significantly low levels in HLA-DR2(p<C0.0l) and D Q 6(p〈0.0001). The corrected P value found only DQ6(p〈0.0005) to be significantly low. This leads DQ6 to be indicative of the possibility of a genetic marker. A further study, howerever, is required on unmedicated, on a larger pool of subjects.