공황장애 및 주정의존 환자들의 혈장 Serotonin과 5-HIAA 농도에 대한 연구

The Study on Plasma Serotonin and 5-HIAA Concentrations in Panic Disorder and Alcohol Dependence Patients

To investigate the serotonergic function of alcohol dependence patients with that o f panic disorder patients, the plasma serotonin and 5-HIAA were measured by H P L C method. The subjects were panic disorder patients(N=8), alcohol dependence patients(N= 10) and normal controls ( N = 10). The results were as follows : 1) Alcohol dependence patients showed lower plasma serotonin concentrations than the other two groups. 2) Alcohol dependence patients had the highest plasma 5-HIAA concentrations among the three groups, and panic disorder patients had higher plasma 5-HIAA concentrations than controls. 3) The ratio of serotonin/5-HIAA in the plasma were lowest in alcohol dependence patients among the three groups, and were lower in panic disorder patients than in normal controls. 4) The total amounts of plasma serotonin and 5-HIAA showed no differences among the three groups. From the results, there were significant differences among alcohol dependence patients, panic disorder patients and normal controls in the ratios of serotonin/5-HIAA in the plasma. Alcohol dependence patients had higher rate o f serotonin metabolism than the normal controls and alcohol dependence and panic disorder patients had biological similarity in serotonin metabolism, suggesting abnormal serotonergic system, different from that of normal controls.