정신분열증환자에서 Haloperidol과 Reduced Haloperidol 사이의 상호변환에 있어 Haloperidol Reductase에 관한 연구

Haloperidol Reductase in Interconversion between Haloperidol and Reduced Haloperidol of Korean Schizophrenic Patients

Haloperidol is metabolized through reductation by the enzyme haloperidol reductase at the benzylic ketone to form an alcohol metabolite, known as reduced haloperidol. The basic and clinical pharmacology of reduced haloperidol and also haloperidol reductase is the main subject of haloperidol study, as the reduced metabolite can be converted back to the parent drug which has some neuroleptic effect This study was undertaken to investigate correlations between haloperiol reductase activity in RBC and reduced haloperidol formation, also the difference of haloperidol reductase activity between responding and nonresponding schizophrenic patient The results were as follows: 1) The haloperidol reductase activity of schizophrenic patients in RBC at 2 weeks was 12.8± 4. 3ng/30 min/200ul RBC, 16.0± 11.9 at 4 weeks and 22.3± 7.1 in control group. There was statistically significant difference of haloperidol reductase activity in RBC between schizophrenic patient and control group at 2 weeks but no difference at 4 weeks. 2) We divided the patient into responding and nonresponding group by the percentage of improvement in total BPRS score as more or less than 2>\% respectively and there was no significant difference of haloperidol reductase activity in RBC among two groups. 3)) There was no significant relationship between haloperidol dose of administration and haloperidol reductase activity in RBC. Considering the above results, haloperidol reductase activity in schizophrenic patients showed different results according to the duration of drug administration, so the study which deal with the factors, influencing the activity of haloperidol reductase, should be undertaken in the future.